I have been leaning toward R gradually. Here are some useful resources in learning and using R:
http://faculty.chicagogsb.edu/peter.rossi/research/bayes%20book/bayesm/Making%20R%20Packages%20Under%20Windows.pdf
http://www.maths.bris.ac.uk/~maman/computerstuff/Rhelp/Rpackages.html
http://www.bioconductor.org/workshops/2006/biocintro_oct/lectures/R_intro.pdf
A good GUI for R is JGR: http://rosuda.org/JGR/
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